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KMID : 0379520210370020261
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한국독성학회지
2021 Volume.37 No. 2 p.261 ~ p.275
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Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice
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Park Dae-Won
Jeon Hye-Lin
Kwon Jeong-Eun
Lee Young-Geun
So Ri-Na
Choe Tae-Hwan
Jeong Yong-Joon
Kang Se-Chan
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Abstract
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N-acetyl-p-aminophenol (acetaminophen, APAP) is a well-known component of analgesic and antipyretic monotherapy products. However, exceeding the recommended dose can lead to serious injury to the liver. We conducted this study to determine the potential of Centella asiatica as a natural substance to protect against APAP-induced liver injury. When acute hepatotoxicity was induced in mice by APAP overdose, their liver weight decreased significantly (p?
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KEYWORD
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Centella asiatica, Triterpenoids, Asiaticoside, N-acetyl-p-aminophenol, Acute liver failure, Hepatoprotective activity
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